|
KMID : 0357920070410010015
|
|
Korean Journal of Pathology
2007 Volume.41 No. 1 p.15 ~ p.20
|
|
|
Immunohistochemical Profile of Acute Cellular Rejection in Renal Allograft
|
|
Park Jong-Ha
Byun Seung-Woon
Park Su-Kil
Yu Eun-Sil
Cho Yong-Mee
Han Duck-Jong
|
|
|
Abstract
|
|
|
Background : We wanted to find an adjunctive marker(s) in renal allograft biopsies for predicting acute cellular rejection (ACR), and so the expression patterns of immune-related molecules were compared between ACR, borderline ACR and non-ACR cases.
Methods : The expression patterns of Fas ligand (FasL), HLA-DR, granzyme B, caspase-3, CD56, interferon stimulated growth factor-3 (ISGF-3), and CD53 were assessed via immunohistochemical study in 75 allograft biopsies from patients with ACR (n=19), borderline ACR (n=22), and non-ACR (n=34).
Results : Compared to those of the non-ACR group, the ACR group revealed an elevated number of FasL positive interstitial inflammatory cells, HLA-DR positive tubular inflammatory cells, cytoplasmic caspase-3 positive tubular epithelial cells, granzyme B positive interstitial mononuclear inflammatory cells and CD53 positive interstitial inflammatory cells. The expression patterns of the borderline ACR group were similar to those of non-ACR group, except for the intensity of FasL in the tubular epithelial cells.
Conclusions : Immunohistochemical investigations of the adjunctive markers FasL, HLA-DR, granzyme B, caspase-3 and CD56 can be useful for making the diagnosis of ACR.
|
|
|
KEYWORD
|
|
|
Renal transplantation, Graft rejection, Cellular immunity, Immunohistochemistry
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|